Angiogenesis In Health And Disease: Basic Mechanisms And Clinical Applications

Outlines strategies for stimulating capillary formation in hypoxia and ischemia and inhibiting it in cancer, diabetes, and chronic inflammation. This state-of-the-science reference highlights recent progress in the ways to promote formation of new blood vessels in ischemic/hypoxic tissue and the means to stifle capillary growth and development in solid tumors, diabetic retinopathy, and chronic immuno/inflammatory disorders such as rheumatoid arthritis and psoriasis. Emphasizes practical clinical applications derived from the latest angiogenesis research. Written by over 80 leading international experts, Angiogenesis in Health and Disease -examines new angiogenic regulators such as angiopoietins and TIE-receptors -describes angiogenic genes such as thymosine B-4, EDG-1, and ARNT proteins -analyzes the role of vascular endothelial growth factor (VEGF) in capillary sprouting -investigates behaviors of endogenous agents of angiogenesis, including cytokines, hormones, chemokines, and peptide and hematopoietic growth factors -explores mechanisms for ameliorating or preventing vascular occlusive disease by induction of collateral artery growth -explains differences in conditions that prompt angiogenesis and arteriogenesis -reviews transgenic and knock-out mice, receptor protein mutations, and other emerging technologies -evaluates angiogenic inhibitors such as angiostatin and endostatin -and more Containing over 3000 references, tables, drawings, and photographs, Angiogenesis in Health and Disease deserves a prominent place on the bookshelves of cardiologists, oncologists, physiologists, hematologists, molecular and cell biologists, biochemists, pharmacologists, rheumatologists, vascularsurgeons, and upper-level undergraduate, graduate, and medical school students in these disciplines.