Apoptosis And Cancer Chemotherapy (cancer Drug Discovery And Development)

This collection of thoughtful and provocative articles focused on the key issues in apoptosis, ranges from the role of apoptosis in defining the response of authentic tumor populations to chemotherapeutic agents to the mechanisms coupling DNA damage to the activation pathway of apoptosis. It reviews the profusion of new signaling, modulating, and effector molecules now implicated in apoptosis and whether other routes to "programmed" cell death may exist. Also addressed are the nature of the molecules that will either constitute targets for future drugs or influence the efficacy of current therapies, as well as mechanistic questions on the control of apoptosis. By focusing on essential questions and critically summarizing the overwhelming tide of recent research results, Apoptosis and Cancer Chemotherapy illuminates not only the potential targets for tumor therapy, but beyond that, potential control points for cancer and such diverse diseases as viral infection, neurodegenerative disorders, and stroke. This collection of cutting-edge reviews by established leaders in the field critically summarizes the recent discoveries concerning apoptosis, cell suicide. The book looks forward to the time when such cell death can be controlled to treat cancer and a host of other diseases as diverse as viral infection, neurodegenerative disorders, and stroke.