Filgrastim In Clinical Practice

Providing a wealth of insights drawn from the experience of groundbreaking researchers working in the field, this Second Edition of a landmark volume brings preclinical and clinical studies of Filgrastim (r-metHuG-CSF) up to date with completely revised and expanded discussions of its biology, biochemistry, structure, pharmacology, clinical applications, and pharmacoeconomics. Explores how Filgrastim reduces infectious complications in the management of cancer, AIDS, severe chronic neutropenia, neutropenia associated with nonmalignant autoimmune diseases, non-neutropenic infections, lymphoma, leukemia, diabetic foot infection, and more Now enhanced with 13 new chapters, Filgrastim (r-metHuG-CSF) in Clinical Practice, Second Edition features novel research as well as provocative and enhanced information on -pharmacokinetic-pharmacodynamic modeling to delineate concentration-response relationships -Filgrastim as treatment or prophylaxis for decreasing infectious episodes, intensifying immunosuppresive therapy, and mobilizing progenitor stem cells -improving granulocyte collection yields from normal donors and neutrophil transfusions in recipients of such products -the potential of peripheral blood progenitor cell (PBPC) transplantation in diseases, such as rheumatoid arthritis -maintaining optimal chemotherapy intensity in situations where dose reduction or delay is necessary -combining Filgrastim with various cytokines, including granulocyte-macrophage colony-stimulating factor, stem-cell factor, rHuSCF, IL-3, and erythropoietin -Filgrastim's toxicity profile, daily aspects of administration, economic impact, and effect on patients' quality of life -and much more Containing over 1650references-more than 600 new to this edition -this truly outstanding Second Edition continues to furnish unparalleled coverage of the subject matter for oncologists, hematologists, infectious disease specialists, immunologists, radiotherapists, oncological nurses, and graduate and medical school students in these disciplines.