APC Proteins

APC Proteins  (English, Paperback, unknown)

Be the first to Review this product
₹18,159
25,419
28% off
  • Bank OfferExtra 5% off* with Axis Bank Buzz Credit Card
    T&C
  • EMI starting from ₹604/month
  • Delivery
    Check
    Enter pincode
      Usually delivered in6-7 days
      ?
      Enter pincode for exact delivery dates/charges
    View Details
    Author
    Read More
    Highlights
    • Language: English
    • Binding: Paperback
    • Publisher: Springer-Verlag New York Inc.
    • Genre: Medical
    • ISBN: 9781461424512, 1461424518
    • Pages: 148
    Services
    • 10 Days Replacement Policy
      ?
    • Cash on Delivery available
      ?
    Seller
    ReproBooks
    1.7
    Announcement
    Seller changed. Check for any changes in pricing and related information.
  • View more sellers starting from 13,444
  • Description
    The initial identification of the Adenomatous polyposis eoli (Ape) gene as the site of mutations in familial adenomatous polyposis (FAP) was described in 1 1992. ,2 A causal relationship between Ape mutations and intestinal tract tumours was confirmed three years later with the establishment ofthe Min mouse model) These mice are heterozygous forApe and develop numerous intestinal tumours that mimic FAP. Subsequently, Ape has emerged as the most commonly mutated gene in colorectal cancerwith reports varying between 50-80% ofsporadic tumours car- rying such mutations. The search for how mutations in Ape initiate and/or support progression oftumours in the intestinal tract has revealed that the Ape protein is a multifunctionalparticipant in a diverse array ofcellular functions. By collecting and assembling the chapters inthisbook, we aimed toprovide an overview of the diverse functions performed by the Ape protein. As summarised in a short final chapter by Trainer,heterozygosityofApe leads to a number ofextracolonic manifestations that further support this emerging picture ofthe Ape protein as an active contributor to many different cellular functions.The first recognised function of Ape was its role in Wnt signalling. o This function is one of the driving forces for how mutations in Ape ensure that cells remain proliferative. Many of the molecular details of this pathway have been discovered and are described in the first chapter by Kennell and Cadigan.
    Read More
    Specifications
    Book Details
    Imprint
    • Springer-Verlag New York Inc.
    Dimensions
    Height
    • 235 mm
    Length
    • 155 mm
    Weight
    • 237 gr
    Have doubts regarding this product?
    Safe and Secure Payments.Easy returns.100% Authentic products.
    Back to top