Infections are the commonest problems encountered in pediatric patients. A rational approach both in diagnosis and treatment is necessary to prevent complications, resistance to antibiotics and ensure cure or control. Various infectious cases are presented here and common problems that are encountered while dealing with these patients are tackled. The cases are represented in a system wise manner. Latest guidelines with evidence based practice are discussed here. This novel case based approach deals with likely dilemmas that one may face when dealing with these infections. UTI, meningitis, pneumonia, TB, diarrhea, bacterial, viral, fungal infections, zoonosis, congenital infections, hospital acquired infections and many more are enumerated in this volume of the textbook.