The use of animals in scientific research has been an area of concern in India, given the sharp polarization of views between animal welfare activists and the scientific community of the country regarding use of animals. In developing state there is a great need for the strengthening of research resource, in view of prevalence of various infectious diseases both emerging re-emerging? There are great numbers of people suffering from diseases still lacking effective cure. These diseases are rare or absent in the developed countries/state which have their own health and other problems requiring the research efforts for their solution. Thus developing countries must carry out effective research on their own problems. In the years to come there will be a need for more and better laboratory animal houses in developing laboratories because of an increased demand for biomedical research, sera, vaccines and drugs. The developing countries/state have specific needs for cheaper drugs, and vaccines to protect their people and animals from existing infectious diseases and the newly evolving disease like Cancer, AIDS etc. Research, in reality, involves three facets: acquisition of new knowledge, use of animals in teaching exercises, and the testing of compounds, chemicals or devices for safety and effectiveness. This book focuses on general introduction of animal experimentations, establishment of animal house in R&D sectors, role and responsibility of Institutional animal ethical committee, skills and procedures of different common experiments on animals. The text is illustrated by top-quality color photos, imaging and diagrams, and key information is highlighted in tabular form. This new handbook provides clear guidance and information on the development of animal handling skills.