After 12 years, vampire Selene wakes up in a laboratory tank. She manages to escape her human imprisonment. On re-entering the world, she finds that humans are aware of both vampire and Lycan species and are fighting to annihilate them. The Lycans are almost extinct, but they are creating more powerful super Lycans. Selene must stop BioCom from creating the new Lycan breed with the help of Detective Sabastian. She also discovers that she has a 14-year-old Vampire/Lycan hybrid daughter.