Visceral Leishmaniasis: Signalling Approaches

Visceral Leishmaniasis: Signalling Approaches (English, Hardcover, Debjani Das (Ghosh))


Visceral Leishmaniasis: Signalling Approaches  (English, Hardcover, Debjani Das (Ghosh))

Be the first to Review this product
20% off
Available offers
  • Bank Offer10% off* with Axis Bank Buzz Credit Card
  • Bank Offer5% Unlimited Cashback on Flipkart Axis Bank Credit Card
  • No Cost EMI on Flipkart Axis Bank Credit Card
  • Delivery
    Enter pincode
      Usually delivered in2 weeks
      Enter pincode for exact delivery dates/charges
    View Details
    Read More
    • Language: English
    • Binding: Hardcover
    • Publisher: White Falcon Publishing
    • ISBN: 9789388459884, 9388459881
    • Edition: 1, 2019
    • Pages: 122
    • 10 Days Replacement Policy
    • Cash on Delivery available
    • 10 Days Replacement Policy
    Despite all efforts on chemotherapy till date, visceral Leishmaniasis caused by Leishmania donovani still remains fatal and widespread. As an intra-macrophage pathogen, the parasite is most successful in exploiting the host cell metabolism, targeting the host protein into phagolysosomal compartment and modulating its phagosome. Even today, because of the complexity of the disease antileishmanial therapy is an incomprehensible subject. The ground reality is that very few agents have adequately been assessed in clinical trials and the most effective agents have the most potential toxic effects and are difficult to administer. As an alternative approach, people are now trying to exploit several surface receptors of host cells, e.g., macrophages for activation purposes to fight against this deadly pathogen, L.donovani. We therefore, thought that attempt could be made to control leishmanial infection either by modulating the surface receptor of macrophage or by identifying the signalling molecules generated say, kinases during early phases of L.donovani-macrophage i.e., ligand-receptor interaction. Identification of these types of molecules would help one to design suitable inhibitors for blocking the infections. Although interaction of L. donovani with macrophages is known to be a ligand-receptor interaction, various aspects of macrophage surface receptor biology including: i] modulation of receptors and its effect on the interaction process and ii] receptor signalling involving cell-cell interaction at the surface remain totally untouched. Work in this area will help us to understand the mechanism of controlling the infections and of intracellular survival of this pathogen.
    Read More
    Book Details
    • White Falcon Publishing
    Publication Year
    • 2019 March
    Book Type
    • Science
    Author Info
    • Author is presently Asst. Professor, Stage-III and Head, Dept. of Zoology, Victoria Institution (College), Kolkata. She did her Ph.D from INDIAN INSTITUTE OF CHEMICAL BIOLOGY (CSIR RESEARCH INSTITUTE) and under Jadavpur University. She was conferred Post-Doctoral Research Fellowship from University of Kentucky, USA, 2002 -2005. She also enjoyed Senior Research fellowship from Lady Tata Memorial Trust. The Author has her long working experience on Leishmania Biology and other aspects of Zoology.
    Have doubts regarding this product?
    Safe and Secure Payments.Easy returns.100% Authentic products.
    Back to top