TEXT BOOK OF PHYSICAL PHARMACEUTICS - l  (Hardcover, Ms. Zankhana Sheth)

Solubility of Drugs Solubility is crucial for a drug's effectiveness, impacting absorption and bioavailability. Expressions like molarity describe dissolution, with interactions driven by hydrogen bonds and van der Waals forces. Understanding solubility parameters and diffusion principles helps predict drug behavior and improve performance. States of Matter and Properties of Matter Matter's states—solid, liquid, gas—each have unique pharmaceutical properties. Phase transitions involve energy changes affecting drug formulation. Vapor pressure and eutectic mixtures are crucial for drug stability and delivery, while polymorphism influences drug development. ### Physicochemical Properties of Drug Molecules Physicochemical properties, such as refractive index and optical rotation, are essential in drug analysis. They determine purity, concentration, and molecular structure. Understanding dissociation constants is vital for predicting solubility and ionization, ensuring drug efficacy and safety. Surface and Interfacial Phenomenon Surface and interfacial phenomena are vital for pharmaceutical formulation. Surface tension and spreading coefficients influence interactions at interfaces. Surface-active agents and adsorption principles are key for designing effective drug delivery systems and ensuring product stability.